SGC-CAMKK2-1: A Chemical Probe for CAMKK2

SGC-CAMKK2-1: A Chemical Probe for CAMKK2

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The serine/threonine protein Neff T56UB50X0 Induction Hob kinase calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) plays critical roles in a range of biological processes.Despite its importance, only a handful of inhibitors of CAMKK2 have been disclosed.Having a selective small molecule tool to interrogate this Freezer Basket Front kinase will help demonstrate that CAMKK2 inhibition can be therapeutically beneficial.Herein, we disclose SGC-CAMKK2-1, a selective chemical probe that targets CAMKK2.